Biography
Biography: Nuray Yazihan
Abstract
Obesity is a complex disorder which also predisposes subjects to other diseases including type 2 diabetes. Inflammation is the common key feature in both diseases. Evidence exists that the inflammation could be induced by hypoxia or vice versa. A hypoxic and inflammatory phenotype has been reported in adipose tissue during obesity. The cellular response to hypoxia is principally regulated by hypoxia-inducible factors (HIFs). Therefore, the present part focuses HIFs-mediated effects of hypoxia in adipocyte inflammation and macrophage polarization associated with obesity pathogenesis.