Day 1 :
Keynote Forum
Sasha Shafikhani
Rush University Medical Center, USA
Keynote: Dysregulated infl ammatory responses lead to enhanced infection and impaired healing in diabetic wound
Time : 09:30-10:20
Biography:
Sasha Shafikhani had completed his undergraduate and PhD studies at University of California at Berkeley and Postdoctoral studies at University of California at San Francisco. He is currently an Associate Professor in the Department of Medicine at Rush University Medical Center. He serves on Editorial Board of six reputable journals. As a Cellular Microbiologist, his group conducts projects that involve bacterial pathogenesis, cancer biology and chronic wound healing
Abstract:
Persistent unresolving inflammation and enhanced bacterial infection are major co-morbidities that contribute to impaired healing in chronic diabetic foot ulcer. Given that the role of inflammatory leukocytes is to combat infection and to jumpstart healing processes, there appears to be a disconnect in the current paradigm that blames impaired healing as a culprit responsible for enhanced infection and holds enhanced infection responsible for persistent non-resolving inflammation in diabetic wound. We have used the cutaneous full-thickness wound models in STZ-injected type-1 diabetic (T1D) rats and db/db T2D mice, to study the early dynamics of inflammatory responses and bacterial infection control in normal and diabetic wound tissues. Our data indicate that in contrast to chronic diabetic foot ulcers which are locked in persistent unresolving inflammation, the acute phase of inflammatory response which is needed to counter invading pathogens early after injury and to jumpstart healing processes is significantly delayed in diabetic wound, thus rendering diabetic wound vulnerable to enhanced infection and impaired healing. Our data further suggest that normal wound tissues express pathogen-specific antimicrobial peptides that preferentially target pathogenic bacteria amongst commensals by recognizing specific virulence structure(s) that are only found in pathogenic but not commensal bacteria. In contrast, pathogen-specific antimicrobial defenses are impaired in diabetic wounds, due to inadequate inflammatory responses early after injury, thus setting the stage for the microbiome shift toward pathogenic bacteria. We further demonstrate that the inability to control pathogenic bacteria leads to persistent inflammatory state and impaired healing in diabetic wound. Importantly, we show that restoring inflammatory responses in diabetic wound early after injury enhances antimicrobial defenses and promotes healing in diabetic wound, indicating that inadequate inflammatory response early after injury in diabetic wound is just as harmful as the persistent inflammatory state that dominates these wounds as they become chronic.
Keynote Forum
Alexander Dreval
Moscow Regional Research Clinical Institute, Russia
Keynote: IVGTT in diagnosing of glucose kinetics dis-balance in diabetic patients
Time : 10:20-11:10
Biography:
Alexander Dreval researches in areas including optimization of treatment and diagnostic methods for diabetes and its complications and mathematical modeling of endocrine systems. He has received the qualifi cation of a Mathematician at M. V. Lomonosov MSU and since 1980 he has been active in the field of mathematical modelingof insulin therapy of diabetes. He has completed PhD and Postdoctoral studies from 1st Moscow Medical Institute. He is the Director of Endocrinology Department of Moscow Regional Research Clinical Institute. He has published more than 300 papers in reputed journals and has been serving as an Editorial Board Member of repute
Abstract:
Introduction: IVGTT in diagnosing of glucose kinetics dis-balance in diabetic patients
Methodology & Theoretical Orientation: Mathematical method (one compartment model of glucose kinetics) for the analysis of Intravenous Glucose Tolerance Test (IVGTT) data is proposed that simultaneously estimates the rate of glucose disappearance from the blood (the k-value) and index of hepatic glucose production (HGP) during the test.
Findings: This method was used for IVGTT data analysis from 107 subjects: 27 diagnosed with DM2, 13 DM1 and 67 healthy volunteers. Based on application of the model to IVGTT data, two discriminant functions were obtained: Distinguishing DM2 from non-diabetic subjects and distinguishing DM1 from DM2 subjects. The 9% of non-diabetic subjects with high HGP estimates also had high k-parameter estimates. This is a pathological condition called “impaired glucose balance” (IGB) and could be considered as the earliest, pre-impaired glucose tolerance (pre-IGT) and pre-impaired fasting glucose (pre-IFG) stage of DM2. One can distinguish 4 variants of glucose dis-balance in overt diabetics depending on the k and H parameter values. It is apparent that seven subtypes of overt DM can be distinguished when one considers a combination of 4 types of glucose dis-balance and two types of DM.
Conclusion & Significance: It is theorized that various subtypes may be expected to respond in diff erent manner to different types of therapeutic interventions. In the oral presentation will be discussed diabetes diagnosing failure in IVGTT and overcome it in our modified method. This method can be useful for in choosing particular diabetic drug, that modify hepatic glucose production in diabetic patients.
Keynote Forum
Saeko Imai
Kyoto Women’s University, Japan
Keynote: Divided consumption of late-night-dinner improves glucose excursions in both individuals with and without type-2 diabetes
Time : 11:30-12:20
Biography:
Saeko Imai is a Professor of Department of Food and Nutrition in Kyoto Women’s University, Japan. Previously, she was a Professor of Osaka Prefecture University and a Biologist with training and research experience at Molecular Nutrition at Graduated School of Life and Environmental Science in Kyoto Prefectural University. She is the Councilor of Japan Society of Metabolism and Clinical Nutrition, Japan Society of Nutrition and Food Science and Japanese Society of Nutrition and Dietetics. She is also a Member of the Japan Diabetes Society, American Diabetes Association and European Association for the Study of Diabetes. She has also authored the book “Eating order diet for Diabetes” in addition to many scientifi c and public policy articles.
Abstract:
Aim: Our aim was to explore the acute eff ect of the late-night-dinner and the divided-dinner on postprandial glucose levels in individuals with type-2 diabetes (DM) and young healthy women (NGT).
Methods: Both 16 individuals with type-2 diabetes and 14 healthy women were randomly assigned to this crossover study. Each participant wore a continuous glucose monitor for 5 days and consumed identical test meals from the second to the fourth day at home. Each participant consumed the test meals of breakfast at 08:00 h, lunch at 13:00 h and the half of the individuals consumed dinner at 21:00 h (D21) on the second day, 18:00 h (D18) on the third day and divided dinner (DD: vegetable and rice at 18:00 h and vegetable and the main dish at 21:00 h) on the fourth day. Th e rest of the individuals consumed DD on the second day and D21 on the fourth day.
Result: D21 demonstrated higher incremental glucose peak (IGP, DM: 6.78±0.79 vs. 3.09±0.62 mmol/L, p<0.01; NGT: 2.74±0.38 vs. 1.57±0.23 mmol/L, p<0.05, mean±SEM) and incremental area under the curve for glucose (IAUC) 23:00-08:00 h (DM: 644±156 vs. 147±63 mmol/L×min, p<0.01; NGT: 271±63 vs. 111±37 mmol/L×min, p<0.05) than D18. On the other hand, DD ameliorated IGP (DM: 3.75±0.58 mmol/L, p<0.01; NGT: 1.96±0.29 mmol/L, p<0.05), IAUC 23:00-08:00 h (DM: 142±60 mmol/L×min, p<0.01; NGT: 80±29 mmol/L×min, p<0.001) and the mean amplitude of glycemic excursion (DM: 5.33±0.41 vs. 6.99±0.60 mmol/L, p<0.01; NGT: 2.34±0.25 vs. 2.91±0.28 mmol/L, p<0.05) than D21 in both individuals with and without diabetes.
Conclusion: Our fi ndings demonstrated that consuming late-night-dinner led to postprandial hyperglycemia and this postprandial hyperglycemia can be ameliorated by consuming DD. Th us, DD could be a practical strategy for individuals who took late-night-dinner to reduce the postprandial glucose levels in both individuals with and without type-2 diabetes.
- Physiology of Diabetes | Diabetic Case Studies | Diagnosis of Diabetes | Diabetes and its complications | Diabetes and Associated Diseases | Diabetes Chronic Complication
Location: Buttes Chaumont
Chair
Alexander Dreval
Moscow Regional Research Clinical Institute, Russia
Co-Chair
Sasha Shafikhani
Rush University Medical Center, USA
Session Introduction
Liaqat Ali Chaudhry
King Salman Armed Forces Hospital, KSA
Title: Prevalence of diabetes-type-2 & pulmonary tuberculosis in Filipinos and treatment out comes: A surveillance study in eastern Saudi Arabia
Time : 12:20-12:55
Biography:
Liaqat Ali Chaudhry is the Head of Pulmonology department as well as a Consultant Pulmonologist of King Salman Armed Forces Hospital.
Abstract:
Objective: To study prevalence of diabetes type-2 and pulmonary tuberculosis among Filipino patients and treatment out comes. Tuberculosis centre of Dammam medical complex (MOH) is a referral centre for the Eastern Saudi Arabia where patients from all government and private hospitals having open pulmonary tuberculosis are admitted for isolation till they are rendered noninfectious. All patients are treated for 6 months under DOTS strategy with 4 drugs (2HRZE) for 2 months as initial intensive phase and 2 drugs (HR) for 4 months as continuation phase.
Method & Material: We retrospectively reviewed clinical records of 1388 patients admitted with open pulmonary tuberculosis between Jan-2003 and June-2010.
Result: Among 1388 patients, 39% (n=542) were Saudis and 61% (n=846) were non-Saudis. Among these 12.39% (n=172) were Filipinos, 153 males and 19 females, respectively. Out of 1388 patients, 114 (7.17%) were found to have diabetes type-2. Among these diabetics, majority n=91 (79.82%) were Filipinos. Sputum conversion was late in diabetic patients resulting in relatively longer hospital stay compared to fellow patients having only tuberculosis.
Conclusion: Our study has shown that one possible risk factor for tuberculosis is diabetes. Majority of TB patients having diabetes type-2, 79.82% (n=91) were Filipinos. Th eir sputum conversion was relatively late and their hospital stay was longer than their fellow patients having only tuberculosis. Our findings are in agreement with the current literature on the correlation of diabetes and tuberculosis.
Custodio Razel
University of the East Ramon Magsaysay Memorial Medical Center Graduate School, Philippines
Title: The effects of Diabetes Self-Management Support and Education through Text-messaging (DSMSET) in the health beliefs, diabetes care profile and HbA1C of diabetes mellitus patients
Time : 12:55-13:15
Biography:
Custodio Razel is currently working with the University of the Philippines-Philippine General Hospital as a nurse. He is a member of the Asia eHealth Information Network of the WHO since 2012 and has been involved in various research endeavors in eHealth adoption with the National Institutes of Health, HIV/AIDS related Stigma and Discrimination with University of the East Ramon Magsaysay Memorial Medical Center and Diabetes Self-Management with SMART Communications Inc and Ateneo Java Wireless Competency Center.
Abstract:
The study aims to explore the eff ects of the Diabetes Self-Management Support and Education through Text-messaging (DSMSET) in improving expanded health beliefs, diabetes care profi le and in decreasing HbA1C of adult patients with diabetes mellitus through automated sending of SMS. A randomized controlled trial, the research is based on the expanded health belief model that upholds sequential goal-settings to improve predictors of appropriate behavior towards glycemic control of the subjects as biological marker of adherence. The researcher together with Ateneo Java Wireless Competency Center developed DSMSET system, a low-cost, two-way text messaging system designed to deliver self-help, educational messages based on the 9 dimensions of health management and can work with SHINE OS+ enabled systems. A total of 122 eligible subjects from UERM PO Domingo OPD Services department of medicine and Sweet Diabetics Club based in CHAMP Wellness Clinic were enrolled. Using simple table random digits, subjects were divided equally to trial arms with n=61 for SMS group and n=61 for non-SMS group. Th e intervention group received DSMSET intervention for 90 days and was required to reply pre-set codes. Both groups answered two sets of survey questionnaires and blood samples were taken for glycated hemoglobin. Data such as demographics for both groups were also collected using SHINE OS+ at baseline and aft er 90 days. At follow-up 110 were subjected to analysis using descriptive and inferential statistics through STATA15 and SPSS23 and were distributed equally. As for the results, the median age of the participants was 64, with 8 out of 10 being female. 54% fi nished secondary education while the average HbA1C is 7.98. As for the results, total expanded health belief scores (8 constructs), diabetes care profi le score, likelihood to take action score of the SMS group increased compared to the non-SMS group with 377.71±33.33 to 398.65±30.86, P=0.0004; 84.4±16.69 to 103.13±14.06, P=<0.001; 26.44±4.80 to 29.31±3.59, P=<0.001, respectively. Combined expanded health belief scores also showed modest improvement in the SMS group with 404.15±34.09 to 427.96±32.38, P=0.001. For HbA1C however, SMS group only posted (-0.01% from 8.11±1.21% to 8.10±1.41%, P=0.963) decrease in the HbA1C while the non-SMS group have increased HbA1C on average. Generally, SMS group and non-SMS groups registered signifi cant diff erences statistically across the constructs, yet no signifi cant relationships were established between HbA1C and the predictors for both trial arms at any moment of the study period. In conclusion, DSMSET demonstrated effi cacy although health beliefs alone may be not suffi cient to take action towards modest glycemic
levels.
Jannel Gentius
The University of the West Indies - St. Augustine Campus, Trinidad & Tobago
Title: Predictors of depression among patients with type 2 diabetes: Examining the impact of anxiety and social support on patients’ psychological wellbeing
Time : 14:00-14:35
Biography:
Jannel Gentius is a Lecturer at the University of the West Indies, St. Augustine Campus and has received her PhD in Psychology. Her research interests include attitudes towards health-related stigmatized conditions, health behavior, attitude change, attitudes towards marginalized groups and mental health. She has a keen interest in research and in developing a strong research culture in the Caribbean. She believes that evidence-based research is critical in understanding and addressing the social, psychological, and economic and governance challenges faced by the Caribbean.
Abstract:
Regardless of the many advances in medicine, there has been an alarming increase in the number of diabetics in the Caribbean. Furthermore, prevalence of diabetes in the region is projected to increase by 148% by the year 2030. The objective of this research was to examine the predictors of depressive symptomology among patients with type-2 diabetics in a Trinidadian sample. Data was collected from 200 patients with type-2 diabetes at hospitals and diabetes clinics in Trinidad using a self-administered questionnaire. The questionnaire measured their anxiety, depression symptomology, perceptions of social support and demographic information such as age and gender. The mean age of participants was M=55 and SD=15.9. Standard multiple regression was used to analyze the data. Multiple regression indicated that the four variables in combination significantly predicted patients’ depressive symptomology R2=0.16, F (4,189)=9.21, p<0.001, with 95% confi dence limits for R2 from 0.07 to 0.25. Th e size and direction of the relationships suggests that depressive symptomology is greatly infl uenced by increased anxiety β=0.34, t=5.05, p<0.001, decreased social support β=-0.14, t=-2.15, p<0.05 and that women experience higher depressive symptoms than men β=0.15, t=2.19, p<0.05. Understanding depression and some of the determinants of depression among persons with diabetes is important for diabetes care since depression can hamper diabetes self-care. Interventions to reduce anxiety and to increase social support of diabetic patients may prove benefi cial in reduction of depressive symptoms and consequently improve diabetes care. Depression management is necessary among persons with diabetes and special focus should be place on women.
Fawaz Alzaid
Sorbonne Universités-Université Pierre et Marie-Curie, France
Title: Transcriptional control of inflammation as an innate immune sensor of metabolic stress in diabetes
Time : 14:35-15:10
Biography:
Fawaz Alzaid is a Research Associate of the French National Institute of Health and Medical Research (INSERM). His recent research highlights include first author publications in Nature Medicine and JCI Insight deciphering mechanisms of tissue infl ammation in diabetes
Abstract:
In type-2 diabetes, sterile infl ammation eff erent from innate immunity is causal in the onset of insulin resistance and progression of complications and comorbidities. However, the precise metabolic stressors and their processing by innate immune cells remain elusive. Our aim is to determine which metabolic factors are immunogenic and to decipher the cellular metabolic pathways that integrate such signals and lead to an Infl ammatory activation. We recently demonstrated that the type-1 interferon response underlies diabetogenic, genetic deletion of its mediator, interferon regulatory factor (Irf)-5, rescues mice from insulin resistance and steatohepatitis. Unexpectedly, the Irf5-defi cient transcriptome in macrophages was characterized by up-regulation of pathways governing cellular lipid metabolism. In this capacity, we propose that Irf5 and its dependent transcripts, act as metabolic sensors, relaying glucolipotoxicity and mediating adaptive cellular metabolism for effective inflammatory activation. To address this we have carried out in-depth analysis of the macrophage cellular energetic and metabolic environment in response to metabolic stressors under Irf5-competence and Irf5-defi ciency. We observed that indeed Irf5 and its infl ammatory targets are responsive to specific metabolic stimuli. In a human study we analyzed Irf5 expression in circulating innate immune cells to determine the prognostic value of innate immunity’s sensitivity to metabolic cues. We observed that Irf5 expression is responsive in circulating cells from type-2 diabetic patients and is associated with specific serological parameters relating to dyslipidemia. Interestingly, Irf5 in monocyte and dendritic cell subtypes is specifically regulated in the presence of vascular and hepatic complications of long-standing diabetes. These data suggest that initiation of the type-1 interferon response is extremely sensitive to metabolic status and may be predictive of disease progression or susceptibility to diabetic complications. Further studies will delineate the pathways linking metabolic cues to activation of Irf5, developing novel immunotherapeutic targets in diabetes.
Abdelkrim Berroukche
Dr Tahar-Moulay University of Saida, Algeria
Title: Assessment of hypoglycemic and hypolipidemic activities of aqueous extract of Trigonella foenum-graecum in streptozotocine-induced diabetic rats
Time : 15:10-15:45
Biography:
Abdekrim Berroukche is currently a Lecturer and Teacher-Researcher, Biology Department, Faculty of Science, University of Saida, Algeria. He has received his PhD in Cell Biology and Nutrition (with Oncology option) from University of Sidi-Bel-Abbes, Algeria. He is Member of Editorial Board of two scientific reviews and is a Peer Reviewer in several journals. He has 32 publications: 30 journal articles and 2 books. He is the Head of research team affiliated to Laboratory of Water Resources and Environment, Biology Department, Faculty of Science, University of Saida, Algeria.
Abstract:
Background & Aim: Diabetes mellitus is a common disease, treated either with insulin or oral anti-diabetics which have undesirable eff ects because of their chemical composition. As an alternative, diabetes could be treated by medicinal plants. This study aimed to assess the eff ects of Trigonella foenum graecum (TFG) seeds aqueous extract on biochemical parameters in streptozotocin-induced diabetic rats.
Materials & Methods: A population of forty (40) rats was divided into 4 groups; normal control, experiment control (diabetic rats by STZ), diabetic treated with TFG at the dose 1 mL (100 mg/mL) and non-diabetic treated (TFG). During 30 days of experiments, body weight and biochemical parameters were measured and statistically analyzed using SigmaPlot soft ware.
Results: No signifi cant diff erence in body weight was observed in diabetics animals (168±8.5 g/L) and animals treated with TGF (167±4.7 g/L). Significant decrease in blood glucose (1.16±0.15 g/L), triglycerides (0.64±0.21 g/L), serum urea (0.38±0.19 g/L) and creatinine (8.02 mg/L) levels were reported in diabetics treated with TFG compared to diabetic animals non-treated.
Conclusion: Trigonella foenum-graecum was able to regulate and maintain glycaemia and lipid profi le at normal levels at diabetic animals.
Zhiyong Zou
Peking University, China
Title: Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China Health and Retirement Longitudinal Study
Time : 16:05-16:40
Biography:
Zhiyong Zou has received his Doctor of Medicine degree in Nutrition and Food Health from Peking University. Presently, he is working as a Lecturer at the Institute of Child and Adolescent Health, Peking University Health Science Center. His research interests are famine exposed and the risk of cardiovascular disease in adulthood; the population intervention of obesity and hypertension in school students. He had participated in Chinese national survey on students’ constitution and health in 2014 as a Member of National Research group and as Co-Investigator to fi nish the fi nal report of Chinese students’ common diseases and health risk behavior surveillance in 2016
Abstract:
Although studies have observed that early life famine exposure linked with hypertension, metabolic syndrome in adulthood, the association with dyslipidemia was unclear. To explore the association between fetal-stage exposed famine and risk of dyslipidemia in adults. 2,752 subjects were selected from the China Health and Retirement Longitudinal Study (CHARLS) 2011-2012 baseline survey to assess the association of fetal-stage famine exposure with dyslipidemia risk in adults aged 50 years. Dyslipidemia was diagnosed as TG/HDLc>5.0 or self-reported dyslipidemia. Birthdates of subjects were used to categorize famine exposure groups. Logistics regression model was used to examine association of famine exposure with dyslipidemia risk. We observed that the prevalence of dyslipidemia among adults in non-exposed, fetus, infant, and preschool stage-exposed cohorts were 15.7%, 23.1%, 22.0% and 18.6%, respectively. Th e early life famine exposure signifi cantly increased LDL cholesterol concentrations aft er adjusting for age. Th e risks of dyslipidemia in fetal (OR 1.58; 95% CI: 1.23-2.03; P<0.001) and infant (OR 1.52; 95% CI: 1.15-2.00; P=0.003) stage exposure cohorts were signifi cantly higher than the non-exposed cohort aft er adjusting for gender and current family economic status. Following gender stratification, we found that fetal (OR=1.80; 95% CI: 1.26-2.57; P=0.001), infant (OR=1.75; 95% CI: 1.17-2.62; P=0.006) and preschool (OR=1.63; 95% CI: 1.10-2.42; P=0.038) -stage exposed to severe famine aggravated the risk of dyslipidemia in female adulthood, however, various associations were not observed for male adulthood. Th erefore, early-life exposure to severe Chinese famine was associated with the higher risk of dyslipidemia in female adulthood, but not in male adulthood. Th is gender-specifi c might be due to son preference hypothesis.
Dalida Badla
Damascus University, Syria
Title: Recurrent pregnancy loss and Poly Cystic Ovary Syndrome (PCOS)
Time : 17:50-18:20
Biography:
Dalida Badla, MD at the age of 27 years from Faculty of Medicine in Damascus and Aleppo Universities .D.MAS from World Association of Laparoscopic Surgeons in 2017. She did fellowship in Assisted Reproductive Technology at WLH, NCR Delhi in 2017. She is head section of Obstetrics and Gynaecology department in Mediclinic Al Bateen, Abu Dhabi. She is a member in MEFS and speaker of many conferences.
Abstract:
Loosing pregnancies before 20 weeks of pregnancy is a frequent obstetric complication and has several reasons such as parental chromosomal anomalies, maternal thrombophilic disorders, uterine structural anomalies and antiphospholipids antibodies. In 50% of cases the pathophysiology remains unknown. The clinical association between RPL (Recurrent Pregnancy Loss) and PCOS is more than common however the incidence rate uncertain till now. The high LH and obesity are risk factor of spontaneous abortion. Hyperinsulinemia has been proposed as pathway for the effect on obesity although its effect on androgen production (theory of Insulin Resistant) acts as a key factor behind PCOS/obesity and risk of RPL. So therefore PCOS, miscarriages symptoms and how to avoid miscarriages with PCOS, their treatment options and then planning to get pregnant again after miscarriage is a great issue now a days.
Raja Chaaba
University of Monastir, Tunisia
Title: Genotypic interactions of genes implicated in lipoprotein metabolism with type-2 diabetes in Tunisian population
Time : 16:40-17:15
Biography:
Raja Chaaba has completed her PhD in Biological Engineering in 2006 and is interested in research about lipids, diabetes and cardiovascular disease. She is a Member of research laboratory “Nutrition-Functional Foods and Vascular Health”, Faculty of Medicine, Monastir, Tunisia. She is an Assistant Professor in Superior Institute of Applied Sciences and Technology, Mahdia, Tunisia.
Abstract:
The relationship between diabetes and lipids is complex. Lipid disturbance can be the result of diabetes but also can be the reason of disturbed glucose metabolism. Apolipoprotein A5 (apo A5), Apolipoprotein E (Apo E) and CETP (Cholesteryl Ester Transfer Protein) are involved in lipoprotein metabolism. To explore the role of genetic variants of apo A5, Apo E and CETP as predictors of diabetes risk and to examine their combined eff ects on type-2 diabetes mellitus (T2DM), 149 type-2 diabetic patients are compared to 101 controls. Th e genotypic frequencies for all three genes alone were associated with increased risk of developing diabetes. Logistic regression analysis of classic coronary risk factors and the genetic polymorphisms demonstrated that B2B2 and CC genotypes of CETP and apo A5 respectively were the most significant contributors to T2DM. However, those genotypes were not associated with higher CETP activity in diabetics. For the three genes, the risk of T2DM in individuals with one risk genotype was 2.5 (95% CI: 2.0-4.1, p=0.004) higher than those with zero risk genotype. Individuals who carried two risk genotypes had a 3.8 (95%CI 3.2-4.8, p=0.018) times higher risk of T2DM than those who did not carry any risk genotypes. Most interestingly, the risk of T2DM for individuals with three risk genotypes was 3.7 (95% CI: 3.5-4.2, p=0.015) higher than those with zero risk genotype. In conclusion, the results imply that genotyping of genes implicated in lipoprotein metabolism could become an important part of the clinical process of risk identifi cation for T2DM.
Saba Noor
Aligarh Muslim University, India
Title: Culture-based screening of aerobic microbiome in diabetic foot subjects and developing nonhealing ulcers
Time : 17:15-17:50
Biography:
Saba Noor is a Research Scholar and presently pursuing PhD in Endocrinology, Faculty of Medicine, Aligarh Muslim University, India. She has completed her Masters and Graduation in Biochemistry from same institute. She has published two articles and two reviews in peer-reviewed reputed international journals and working to improvise diagnostic tools implemented in exploring microbial spectrum and immunological studies among diabetic foot patients.
Abstract:
The study was carried on diabetic foot patients to deduce clinical attributes, the occurrence of the range of aerobic microbial fl ora and to assess their comparative in vitro susceptibility to the customarily used antimicrobials. We also studied the potential risk factors involved in the development of non-healing ulcers. A total of 87 organisms were isolated from 70 specimens, including Escherichia coli (19.5%) among the Gram-negative and Staphylococcus aureus (18.4%) among the Gram-positive as the predominant aerobes explored. Pseudomonas aeruginosa and Escherichia coli were predominant isolates of non-healing ulcers. Th e antimicrobial sensitivity pattern revealed that Vancomycin (100%) and Amikacin (90.4%) exhibited highest sensitivity to Gram-positive cocci, while all strains of Pseudomonas aeruginosa were sensitive towards Imipenem (100%). Th e prevalent of uncontrolled glycemic status, altered lipid spectra, the existence of neuropathy and peripheral vascular disease, suggested the predisposition towards the development of non-healing lesions. Th e study has underlined the need for continuous surveillance of bacteria and their antimicrobial sensitivity blueprints to provide the basis for empirical therapy and to minimize the risk of complications. Further, stringent clinical evaluation and medical history will help in revealing the risk of developing non-healing status in diabetic foot ulcers.