Sunita Singh
Banaras Hindu University, India
Title: KCNJ11 gene polymorphism E23K (rs5219): An Association study in Type 2 diabetes mellitus in Indian population of eastern Uttar Pradesh
Biography
Biography: Sunita Singh
Abstract
Despite a very large burden of type 2 diabetes in India, insight into the genetic architecture of Type 2 Diabetes (T2D) in Indian population of eastern Uttar Pradesh is currently lacking. Genome-wide association scan studies (GWASs) have led to the discovery of several novel genetic markers associated to Type 2 diabetes (T2D). Multiple studies have demonstrated reproducible association of several genetic markers (SNPs) with T2D risk, each making a modest contribution to the overall risk mainly in European populations. Only a few investigations for T2D susceptibility genes have been reported in South Asians. Recent studies suggest that the KCNJ11 gene, which encodes the Kir6.2 subunit of the ATP-sensitive potassium (KATP) channel, may also be a candidate diabetogenic gene. The E23K KATP channel polymorphism has received much attention recently due to its higher frequency in the Caucasian type-2 diabetic population. The variant E23K (rs5219) of KCNJ11 has been demonstrated to have modest association with T2D in European, Japanese and North Indian populations. In the present investigation, we have studied the association of KCNJ11 (E23K) (rs5219) gene polymorphism to T2D in the Indian population of eastern Uttar Pradesh in 240 cases and 229 ethnically matched control subjects. Our data show weak association to T2D with odds ratio 1.086 (95% CI 0.832-1.416; P = 0.544). Our data also show association to T2D under co-dominant model only.