Julieta Palomeque
University of La Plata, Argentina
Title: The heart with impaired glucose tolerance: a time bomb
Biography
Biography: Julieta Palomeque
Abstract
Heart failure and arrhythmias occur more frequently in patients with type 2 diabetes (T2DM) than in the general population. T2DM is preceded by a prediabetic condition, characterized by impaired glucose tolerance or impaired fasting glucose, marked by elevated reactive oxygen species (ROS) and subclinical cardiovascular defects. Moreover, multifunctional Ca2+ calmodulin-dependent protein kinase II (CaMKII) is ROS-activated and CaMKII hyperactivity promotes heart disorders. However, a link between prediabetes and CaMKII in the heart is unprecedented. The aim of the present study was to prove the hypothesis that increased ROS and
contribute to the initial events in the development of heart failure and arrhythmogenic mechanisms, life-threatening in the overt T2DM