Mehtap Kacar
Yeditepe University, Turkey
Title: The roles of macrophages polarization in the pathophysiology of diabetic atherosclerosis
Biography
Biography: Mehtap Kacar
Abstract
Diabetes is associated with increased risk for atherosclerosis. Atherosclerosis is a chronic inflammatory disease. The increased inflammation and accelerated atherosclerosis are observed in diabetic patients. The inflammatory response in the pathogenesis of atherosclerosis is generated by interactions between plasma lipoproteins, monocytes/macrophages, T lymphocytes, endothelial cells, and smooth muscle cells as well as the extracellular matrix of the arteries. Macrophages are the most important cells in pathogenesis of atherosclerosis, and play main roles in generation of foam cells which produce inflammatory mediators. M1 and M2 macrophages present in the atherosclerotic plaques. M1 macrophages play an important roles in the development of plaque, on the other hand M2 macrophages help to regression of inflammation. Hyperglycemia and advanced glycation end products (AGEs) effect macrophages polarization.