Saeko Imai
Kyoto Women’s University, Japan
Title: Divided consumption of late-night-dinner improves glucose excursions in both individuals with and without type-2 diabetes
Biography
Biography: Saeko Imai
Abstract
Aim: Our aim was to explore the acute eff ect of the late-night-dinner and the divided-dinner on postprandial glucose levels in individuals with type-2 diabetes (DM) and young healthy women (NGT).
Methods: Both 16 individuals with type-2 diabetes and 14 healthy women were randomly assigned to this crossover study. Each participant wore a continuous glucose monitor for 5 days and consumed identical test meals from the second to the fourth day at home. Each participant consumed the test meals of breakfast at 08:00 h, lunch at 13:00 h and the half of the individuals consumed dinner at 21:00 h (D21) on the second day, 18:00 h (D18) on the third day and divided dinner (DD: vegetable and rice at 18:00 h and vegetable and the main dish at 21:00 h) on the fourth day. Th e rest of the individuals consumed DD on the second day and D21 on the fourth day.
Result: D21 demonstrated higher incremental glucose peak (IGP, DM: 6.78±0.79 vs. 3.09±0.62 mmol/L, p<0.01; NGT: 2.74±0.38 vs. 1.57±0.23 mmol/L, p<0.05, mean±SEM) and incremental area under the curve for glucose (IAUC) 23:00-08:00 h (DM: 644±156 vs. 147±63 mmol/L×min, p<0.01; NGT: 271±63 vs. 111±37 mmol/L×min, p<0.05) than D18. On the other hand, DD ameliorated IGP (DM: 3.75±0.58 mmol/L, p<0.01; NGT: 1.96±0.29 mmol/L, p<0.05), IAUC 23:00-08:00 h (DM: 142±60 mmol/L×min, p<0.01; NGT: 80±29 mmol/L×min, p<0.001) and the mean amplitude of glycemic excursion (DM: 5.33±0.41 vs. 6.99±0.60 mmol/L, p<0.01; NGT: 2.34±0.25 vs. 2.91±0.28 mmol/L, p<0.05) than D21 in both individuals with and without diabetes.
Conclusion: Our fi ndings demonstrated that consuming late-night-dinner led to postprandial hyperglycemia and this postprandial hyperglycemia can be ameliorated by consuming DD. Th us, DD could be a practical strategy for individuals who took late-night-dinner to reduce the postprandial glucose levels in both individuals with and without type-2 diabetes.